Numerous smart drug aficionados are claiming PRL-8-53 as one of the top cognitive enhancers for short term memory boosting. Although the drug was patented around forty years back, it has only been subject to a single human trial. Further testing is required to establish its efficacy and risk profile as medical facts. Nevertheless, nooptropics fans are keenly interested in its effects.
PRL-8-53’s full chemical nomenclature is Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate). It is a synthetic compound first formulated in 1972. Dr. Nikolaus Hansl patented it in 1975 whilst working as a neuropharmacologist for Nebraska’s Creighton University. Early tests involving animals revealed the substance to be safe and also strongly nootropic, given that it increased avoidance learning when given to rats and produced no side effects. Major interest into the benefits of PRL-8-53 was generated by a human trial conducted in 1978. This study demonstrated that a dose of PRL-8-53 could more than double word retention test scores.
Further interest in PRL-8-53 was stimulated by the remarks of longevity expert and novelist, Durk Pearson. Mr. Pearson said to the publication High Frontiers that PRL-8-53 is an excellent memory booster. He said that that generally one can memorize up to 8 numbers by studying them for about one second but that PRL-8-53 allowed a person to recollect up to 22 numbers.
So far, the only human PRL-8-53 trial has shown strong evidence of nootropic potential. This study was financed by Dr. Hansl soon after patenting the substance. The trial recorded word retention rates among a set of thirty healthy subject, aged between 86 and 24. Test subject with already good starting word retention rates demonstrated only minor improvement when using PRL-8-53, however those aged over thirty and those with poor word retention rates were able to more than double than their scores. For purposes of this trial, 5 mg. doses of PRL-8-53 were administered.
Reports from users also indicate and support PRL-8-53’s nootropic benefits to short-term memory. However, the drug is still considered as experimental due to insufficient testing. This subject is not listed as a scheduled substance within the US and so may be legally bought without needing a prescription.
PRL-8-53’s Effect and Advantages
The major positive effect of this drug is improved memory.
In the single human trial of this drug, older people taking PRL-8-53 were shown to experience dramatic improvements in recall following consumption of 5 mg. of PRL-8-53. The study was conducted using a double-blind methodology and measured the ability to memorize a list of a dozen single-syllable words. First, a wordlist was memorized without benefit of the drug and the results compared to a second round when either the drug or a placebo was taken. In all cases, participants were asked to recall the wordlist on the following day and then one week subsequently.
The final results clearly show that those with high initial scores demonstrated little improvement when taking PRL-8-53. However, those aged over thirty and those with lower initial scores did show marked improvement.
Dr. Hansl wrote an article about the test, in which he discussed these results in greater detail. Regarding those aged 30 or older, he wrote that those given a placebo recalled 3 out 12 words correctly after 24 hours has passed. After one week had passed, the average score was just 2 words. The very same participants, after receiving the substance, scored much higher. They achieved an average 5.85 words correctly after a full day and after one week got 5.25 words correct. Such results are significant, statistically. The greater performance, measured against placebo pills, was 108% better for the full day test and for the week test, 152% better.
These results are confirmed by many nootropic fans who experimented with PRL-8-53 and observed these memory-enhancing effects for themselves. Many then reported such experiences and some compared PRL-8-53 favorably to similar cognitive enhancers such as Noopept and Nerifacetam.
How PRL-8-53 Works
The precise way in which PRL-8-53 achieves its effect is currently unknown. It is theorized that it regulates the production of a number of vital neurotransmitters in the brain. Dr. Hansl wrote in the reports of animal and human trials about PRL-8-53’s ability to potentiate the neurotransmitter dopamine as well as limit serotonin production and boost the neural responsiveness to acetylcholine. Dr. Hansl’s 1978 paper on the human trial certainly hints at such actions without fully describing the drug’s mode or operation.
Given that older participants in the trial experienced the most notable benefits, it suggests that the modulation of dopamine is indeed a factor in PRL-8-53’s effectiveness. Re-establishing levels of dopamine production, which decline with age, is certainly a credible mechanism for enhancing both memory and learning.
Dr. Hansl wrote an article in 1979 detailing how memory and learning might be enhanced through pharmacology. In it, he stated that PRL-8-53 was proven to boost responsiveness to noradrenaline in animals in both central and peripheral ways. From this fact, he theorized that it was reasonable that a comparable effect may be produced in people. In terms of behavior, he felt it was implicit that PRL-8-53 might be helping in the conversion process between short and long term memory, leading to improved storage of all memories.
In that article, Dr. Hansl also stated that PRL-8-53 was demonstrated to increase systemic responsiveness to acetylcholine and that this response was comparable over a significant range of doses which forbade the possibility of accidental overdose.
Dr. Hansl went on to deny that PRL-8-53 could be classified as a stimulant. He said it’s very safe as the animal studies showed that any toxic effects appear only at 1000x the recommended dose for humans. He said that he has developed what might possibly be an extremely helpful drug which targets a very specific brain pathway, specifically the cholingergic system, and has the useful effect of enhancing memory and information-recall from studied material.
Through the human study, the only dosage given was a single 5 mg. dose, taken daily. Currently, no information exists on whether this is the optimum dose or whether it may cause any side effects.
As there is little in the way of definitive information regarding PRL-8-53’s effects and interactions, it is recommended that it not be used in combination with other nootropics, drugs, supplements, etc.
During the course of the human trials, no side effects from the 5 mg. dosage were reported. The animal trials demonstrated that an extremely concentrated dosage is necessary to produce any toxicity. In other words, there is only very limited evidence of no short term side effects and no definitive answer as to whether the substance causes side effects in the long-term.
Where to buy PRL-8-53
As this is a relatively obscure and experimental smart drug, it’s best to be absolutely sure of your intended vendor’s trustworthiness. Many people are looking to buy PRL-8-53. We strongly recommend dealing only with well-established vendors with good reputations. One such vendor was Powdercity although it seems they no longer stock PRL-8-53. It is recommended that you search for products which are tested by third party laboratories in order to assure your product is genuine and effective.
The first few times of using PRL-8-53 are usually stronger experiences but with days off in between there hasn't really been tolerance to the main effects for me. Reading from the original studies there were still noticeable effects above baseline at 24h and minor levels at 48h so we can assume that daily use would get tolerance due to overlapping doses, however the doctor that discovered it supposedly took it daily for the rest of his life. Its a very efficient cognitive stimulant for me without any of the side effects of CNS stimulants, and its still a favorite of mine even though I only use it maybe once a week now.
I am using it now. Here is my experience from AM. PRL-8-53 is crazy for memory recall. It helps me to memorize information better and provides noticeable increases in ability to recall information. Here is an example. I am doing a kitchen bid proposal and going over all the different finishes. Instead of constantly looking at my notes, I am able to I remember almost all of ideas. The best part about this is my client notices this too. After trying different dosages, I now use 10mgs. It kicks in quick and taste horrible.
The whole nootropic thing really intrigues me. I started researching and using them about 2 years ago. I started with the basics ALCAR, Choline Bitartrate, herbals and my 1st racetam was Piracetam. It was just a matter of testing them on myself and seeing which ones actually worked for me. I used all the different vendors until I found the best.
For me my perfect stack would be:
A. SEMAX or noopept for to boost my creativity and concentration.I am able to perceive colors and objects in HD fashion. I really like Semax vs noopept
B. PRL-8-53 for the memory boost.
C. Phenylpiracetam, Modafinil, Armodafinil to boost mental focus.
My experience is great ! My memory was so sharp it was scary :D (though I did use it with some other stuff). One thing to remember is there are NO clinical trails no test nothing about this substance so if we grow 3rd arms from the chest 20 years from now lets start a club
I am very sensitive to stimulants (too much can cause/worsen a migraine) so even though PRL has no physical stimulation the mental stimulation is strong enough to push that edge for me depending on dose. Theanine is enough to mellow it out on its own though, Picamilon is what I usually take as a non-tolerance level GABA source, its a subtle effect but helps to buffer from stim-headaches.
PRL-8-53: in Summation
PRL-8-53 has tremendous potential as a synthetic smart drug which could greatly increase people’s powers of recollection. Further research needs to be conducted.
While the drug stimulated a great deal of excitement when it was first developed nearly 40 years ago, unfortunately medical investigation slowed down to a crawl since then and no further testing was conducted beyond the initial animal and human trials. More studies are necessary to determine if the drug lives up to its promise.
Sadly, there is currently no major effect afoot to investigate this substance’s benefits. Nevertheless, word of mouth is spreading and many nootropic fans are trying out the drug for themselves.