Ambien vs Belsomra vs Lunesta vs Sonata
Since the beginning of the 90s, the majority of sleeping pill prescriptions were written for drugs whose method of action depends upon boosting GABA levels in the brain. GABA (gamma-Aminobutyric acid) is a neurotransmitter which dampens the firing of neurons to calm brain activity. GABA works by suppressing Orexin, another neurotransmitter which increases alertness.
Belsomra is a soporific which uses this same mechanism to suppress wakefulness in the brain and so aid sleep. It’s very popular due to its strong marketing drive, which promotes the drugs via TV adverts, a website and even its Sleep Guru app. A single month after it was approved by the FDA and released by Merck Pharmaceuticals, physicians were issuing as many as four thousand prescriptions for Belsomra per week.
Belsomra has sold extremely well, so much so that GlobalData, a UK consulting firm, has forecast Belsomra to be the best-selling soporific within an 8 year timeframe. This is especially significant given that in the USA alone, over 42 million soporific prescriptions are written per year.
Certain sleep researches are concerned that Belsomra’s rising popularity is driven more by marketing than clinical results. Testing has revealed that Belsomra is not superior to competing soporifics, such as Ambien or Lunesta. In fact, all such meds have been proven to have lower effectively and possibly higher cost than therapies, such as Cognitive Behavioral Therapy (CBT). This is a type of psychotherapy which is good for relieving anxiety and stress, this in turn often leads to improved sleep.
The root cause of insomnia is inappropriate night-time over-activity of those neurotransmitters which promote alertness. Therefore, suppressing those neurotransmitter pharmacologically should alleviate insomnia. So says Dr. Gregg Jacobs, a specialist at the UMass Memorial Medical Centre’s specialty Sleep Disorders Centre.
Jacobs told The Huffington Post, an online news blog, that insomnia stems from improper sleeping habits which contribute to an increase in alertness neurotransmitters. He believes that directly targeting those neurotransmitters rather than trying to teach new sleeping habits will ultimately prove ineffective. Belsomra has been FDA-approved as a soporific, however in clinical testing its effectiveness at alleviating insomnia is limited.
Jacobs addressed such finding by saying that while the drug is very pricy, it has only minimal impact on sleep. He stated that the maximum dose of 20 mg. which has FDA approval, only gives an average 16 more minutes of sleep to users. He said such results are medically meaningless. It was also found that trial participants fell asleep on 6 minutes before those given a placebo.
Even though Belsomra is marketed as having few side effects than competing soporifics, due to its more focused nature, criticism has been leveled at its most significant side effect; that being major drowsiness the day after taking it. During the course of FDA trials, those given the drug at the experimental dosages of thirty to forty milligrams were shown to experience so much drowsiness the next day that the recommended dosage was lowered to twenty milligrams.
Even at the recommended dosage of 20 milligrams, it is not uncommon for users to suffer from drowsiness the following day. This side-effect can impair driving ability as well as decision-making. It may even interfere with balance and coordination in the more elderly. Dr. Jacobs pointed out that Belsomra may stay in the system for up to 72 hours before being fully processed. It is this endurance in the body which leads to a “drowsiness hangover.”
Doctors Steven Woloshin and Lisa Schwartz, both experts on drug safety, informed Consumer Reports that Belsomra has another concerning adverse effect; causing users to experience a feeling of paralysis whereby they can’t speak or move.
Different experts are less alarmed over the trial results. Dr. Thomas Roth, an expert in sleep medicine who frequently consults with major pharmaceutical firms such as Merck, was also contacted by HuffPo. He commented that the safety of Belsomra appears to be entirely comparable with that of other common sleeping aids. Megan Wilkinson, Merck’s Global Director of Communications, pointed out that Belsomra has no special cautions or indications regarding its usage when compared to other common sleep aids. Nevertheless, Belsomra and similar medications are often not the first choice of many doctors when treating insomniacs. Indeed, such medications are sometimes seen as a last resort due to their side effects.
Sleep specialists maintain that sufferers of insomnia, which is defined by long-lasting difficulties with falling and/or staying asleep which impair regular daytime function, should first look into healthy sleep habits.
Ambien is considered to be more effective than Belsomra. Belsomra is aid to help only about one third of insomniacs, whereas Ambien helps more people. If however you’re one of those who find Belsomra effective, it is a safer long-term treatment than Ambien, which can have a detrimental effect on the brain.
Perhaps the best medical option, all things considered, is to take Belsomra along with the “natural” sleep aid, melatonin. Other pharmacological options, such as benzodiazepines and z-drugs, have the potential to damage cognitive processes. Nevertheless, for some insomniacs there is no better option than Ambien and they cannot sleep normally without it.
Belsomra has a fairly long half-life (the time until its presence in the body is halved) of ten hours. This is both good and bad. It is the reason why one can “sleep through” when using it, without waking up early. However, it can also lead to morning grogginess, which can even last later into the next day. However, this “hangover” is fortunately less pronounced than that which is often induced by antihistamine soporifics, such as diphenhydramine or hydroxyzine. These antihistamines can take over 24 hours to be fully eliminated from the body.
Finally, Sonata (Zaleplon) is the least effective soporific and has a very fast half-life of only one hour. This drug is mostly taken right at bedtime as a sleep inducer. It will help a user who has trouble getting off to sleep but won’t be of any help to those who tend to awaken during the night.
Advantages and Effectiveness of Sonata and Zaleplon
Sonata’s purpose is to aid falling sleep. Sonata and Lunesta works by reducing the time it takes to fall asleep. The body rapidly processes Sonata so its effects are fleeting. It will not lengthen total slumber nor will it reduce the incidence of waking up during the night. Sonata takes effect within ten or twenty minutes of administration so it should be taken immediately prior to bedtime. Sonata’s effects are faster than Ambien (zolpidem).
Speaking of waking up during the night, Zaleplon is good for this. It can be taken if you wake up too early and should put you back to sleep. It last for roughly 4 hours so it’s best not to take it just before your alarm clock goes off. Zaleplon is good in that it carries a low risk of grogginess or a “hangover” the next day. This is true even if taken in the small hours. Zaleplon is processed by the body very rapidly so its effects do not linger. One more positive aspect of Zaleplon is that it’s unlikely to cause rebound insomnia after its usage is ended.
Side-Effects and Negative Aspects of Sonata, Lunesta and Zaleplon
Both drugs can cause minor adverse effects like dizziness, headaches and grogginess. In the event that you must get up in six hours or less (or four for Zaleplon), it’s better not to take a sleeping aid as you’ll likely feel very sluggish in the morning.
Sonata and Lunesta may cause a degree of forgetfulness. If you experience any loss of memory, stop taking Sonata in instances where you will be able to sleep for less than four hours. The brain may struggle to form new memories while still under the influence of Sonata.
Zaleplon may be addictive, particularly if it is used over a long period of time and / or in high concentration. It should not be taken for longer than three consecutive weeks without a break; the more frequent breaks can be taken the better.
Both drugs may give rise to withdrawal symptoms, especially in cases where it is relied upon for a long period and stopped suddenly. The withdrawal symptoms may include fractiousness, excess perspiration, stomach discomfort, anxiety or low mood.
It is possible to build up tolerance to Sonata if it’s taken frequently. This means more must be taken to achieve the same effect.
Another potential pitfall of Sonata is rebound insomnia, whereby your sleeping patterns actually become worse than before you started taking the drug for the few days after you stop taking it.
Sonata may also cause aberrant behavior, similar to instances of somnambulism. In rare cases, people may perform regular waking activities while in an unconscious state.
Depression may be caused in rare cases by the use of such soporifics.
Sonata is a Schedule IV substance, meaning it is controlled by law and only available via prescription.
Getting high from Ambien, Belsomra, Lunesta and Sonata
Many people are searching for the way to get high from Ambien, Belsomra, Lunesta and Sonata. Sleeping medications are often abused but this happens if one takes it in higher dose or during a totally different way than drug is prescribed, or if one buy it overseas without any prescription. As a result of their effects like appetite suppression, increase of focus and brain activity, spotlight, they're often abused for a functions of weight loss or performance improvement . It is often used by student to get their study results higher. Due to a fact Ambien, Belsomra, Lunesta and Sonata medicines may give you euphoria, these medicine also are often abused for recreational functions , in other words to get high. Euphoric effects from stimulants are mostly generated once one crashes a pills and mixed with water, or snoted and later injected. There are major forums like drugs-forum.com or bluelight org where people discus the high from Ambien and other related drugs. It is strongly not recommended to get high from the drugs that cause addiction and serious side effects for a healthy human.