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Dihexa: review, experience, comparison to Ang-IV


Traditionally used to treat Alzheimer's Disease, Dihexa is a drug that stimulates nerve synapse generation. Only recently this drug became more accessible to the nootropic community, but it is still considered difficult to obtain, by modern standards.

A lot of the information surrounding this substance is shrouded in mystery, because it is difficult to find substantial research data is available to the public. As a result, the mechanism of action is poorly understood by the regular users of nootropics. We deeply explored this drug and found relevant information that describes this mechanism.

Based upon our research, we will present information that correlates to the history of Dihexa, as well as clearly defining it's structure. Within the content of this article you can find information that compares Dihexa to another substance in the category, as well as an explanation of the action mechanism of the drug.

The article is wrapped up with information correlating to personal experiences of users that have shared their story publically on the internet. We tried to compile relevant information, but it's safe to say that those stories are to be used purely as reference, and shouldn't be taken for granted.


History of Dihexa

Through the research on cerebral influence over heart functions in Joseph W. Harding's laboratory a lot of drugs were created that strived to provide inhibition of angiotensin. This neuropeptide is the major factor in coordinating information between the brain and the heart. The main objective of the research was to create drugs that will prevent the appearance of cancer by lowering the prostaglandin levels in the body.

Through the course of their research, the scientists at these laboratories discovered that a sequence of angiotensin lacked the expected hypertension effect that the other sequences featured. Upon discovering the research created by one of his colleague's about angiotensin's opposite hormone, Joseph's interest into the substance grew exponentially. He discovered that the specific sequence called angiotensin IV (Ang-IV) was perfectly correlated within the structure of the opposite hormone, which explained the missing effect to a certain extent.

He made efforts to research more about Ang-IV and he discovered that a great amount of concentration in the hippocampus, which suggests that this drug plays a role in memory creation. Through this find, he applied for a grant with "Eli Lilly and Company", a pharmaceutical corporation known for the production of Prozac, which enabled him to further his research into the substance, eventually leading to the creation of Dihexa.

Research was halted for a brief period of time, when Eli Lilly had to stop funding due to lawsuits correlating to the birth defects caused by Prozac. The research was restarted at the beginning of the new millennium when Harding and his collaborators started anew.



The research into Ang-IV and its analogues showed promising results and some grave challenges. Harding successfully healed brain damage by directly injecting the substance into the peritoneum of animals. The positive results were repeated across a wide spectrum of cognitive afflictions, where the analogues of Ang-IV demonstrated their healing power.

The main challenges to create a pharmacological product from this substance, was getting this it to naturally pass the blood-brain barrier and increasing the duration of the effects. Without solving these challenges it would be impossible to create a product that would be easy to use and provide value for consumers. This was the time when funding into the research halted and the project was abandoned.

Fortunately for Harding, the leader of Eli Lilly and Company at the time resigned, which meant that he was the owner of the intellectual property that was generated by the initial research.

This prompts him to restart the research and discover a way to bring this amazing drug to the market. With the help of his colleagues, Harding managed to isolate the main peptides correlating to the beneficial properties presented by one of the analogues to Ang-IV. He managed to isolate a working analogue consisting of three peptides. This analogue showed stability and an ability to merge with body fats, thus bypassing the blood-brain barrier. The promising results of the research attract additional investors and Harding is able to find the perfect analogue of angiotensin IV, called MM-201. This substance allowed test mice subjects to heal brain damage to the point where they were in a better condition than the control subjects. Satisfied by the results of the research, Harding eventually creates a pharmaceutical product named Dihexa.
Structure of Dihexa

Dihexa compared with Ang-IV

When compared to Ang-IV, it seems that Dihexa is light-years ahead. In a case study conducted by prominent researchers, where they treated mice neurons for 5 days with different substances, Dihexa manages to demonstrate a significant increase of dendritic tissue generation. Ang-IV falls quite short from Dihexa's impressive results.

Today Dihexa is considered a chemical miracle by scientists and medical workers, which is the reason why it's commonly used to treat the negative effects of Alzheimer's Disease and provide relief to people that are afflicted. Logically, one can see how this substance can be very appealing to a person interested in nootropics, mainly because research proves the positive effects to memory when using Dihexa.


Mechanism of Action

Dihexa acts as an activator for growth factor hormones, by providing the necessary conditions for their activation. Without such a signal, these hormones remain apart in the nerve cells, and usually the healing process is conducted once they merge together. Because of this, Dihexa's mechanism of action is described as dimerization, which means the process of two parts, which is the natural state in which these hormones are stored in nerve cells. With the onset of Dihexa, these hormones are merged into their complete form and the regeneration process begins. By measuring levels of hepatocyte growth factor, secreted by the liver researchers measure the onset of neurodegenerative disease. Dihexa causes the body to create elevated levels of this hormone, suggesting the facilitation of healing.

Through the process of dimerization of hepatocyte growth hormone, the enzyme c-MET is also activated which plays an important role into DNA-binding protein management, where it acts as a regulator for other enzymes dis/allowing them to produce specific proteins from gene expressions.
Mechanism of Action


Controversial research into cancer suggests that while Dihexa's effects are viable for people dealing with heavier afflictions, it isn't recommended for healthy individuals. The reasoning behind this statement is that through the dimerization process of growth hormone and the activation of the enzyme c-MET, any latent cancer cells could potentially be awoken. These statements come from contemporary research focusing on the prevention of cancer, where the dimerization of growth hormones is considered to be a negative outcome. The growth hormones have beneficial effects for every cell in the body, helping the body recuperate damage of any kind, but it doesn't have the capabilities to identify cancerous cells, thus it provides increased performance to them as well. Growth hormones are naturally released into the body throughout the duration of your life, but as people get older the glands responsible for creating these hormones produce less and less.

Dihexa is the first of its kind to incorporate this process into regeneration of cognitive function, turning conventional knowledge upside-down. The research is conclusive, as Dihexa can positively influence the healing of wounds, muscle atrophy, various neurological afflictions and organ damage. The risk is that increased levels of growth hormones can benefit cancer cells as well which potentially leads to extremely unwanted consequences. There seems to be a fine balance when considering the usage of Dihexa, since it's a miraculous and powerful drug that can facilitate the regeneration of various life-breaking afflictions. There hasn't been any substantial efforts to improve Dihexa and find a way to mitigate the potential negative side effects, since Harding.

This brings about questions, as to why such a promising drug that has shown incredible results is completely abandoned. Reasoning suggests that one of the major factors is the economy, where without the help of pharmaceutical giants and their sizeable financial investments, it is rather impossible to get approval from the FDA.

Another reason suggests that due to the novelty surrounding the drug, a lot of researchers avoid working with it, due to the lack of substantial previous research with human subject. Except for Harding, nobody else has done any public research of Dihexa. Commonly doctors do not bother to educate themselves about this drug, since other less effective alternatives are used to treat Alzheimer's.

In general, there is substantial research of Dihexa in animals, where it has demonstrated an average half-life of about the length of a week, significantly longer than other substances capable of restoring brain function. The drug also regenerates the various systems involved in the regular production of dopamine and noradrenaline, which suggests a capability of healing depression.


Dihexa experiences

We went through the controversial history, mechanism of action and pharmacological interests, yet one very important question is left unanswered.

What are the effects of Dihexa when a healthy human being consumes it?

Formally, Dihexa has never been tested on humans. It is expected that when a healthy person takes this drug, the current chemical state of his organism, the way it is consumed and the genetic structure of the individual play a huge role in whether the drug will boost development.

There are many curious individuals in the world and some of them have tried and shared their experience with Dihexa. Users disclose taking dosages ranging from 5mg to 45mg of Dihexa per day and have reported a wide array of benefits, including boosted mental endurance, ease of creative expression, increase conversational skills, and higher aptitude for solving problems, among other things. There are also those individuals that tried the drug, but did not feel anything, or in other words they were un-responsive.

One person had an experience of using a solution made with Dimethyl Sulfoxide and Dihexa with concentrations of 16mgs per mL. Three doses across the span of a week, each one taking place every other day. He reported a transformative experience, that included an increased creative capabilities, problem-solving skills and significantly boosted his ability to clearly communicate his ideas and emotions. The person also reported that through the increased capabilities of logical workings in his mind, he felt that his critical thinking was heightened, as he was clearly able to grasp onto concepts faster and make better logical conclusions during his conversations with other people.

These reports are personal, and completely informal which means that the experiences were not measured scientifically. Regardless, it seems that we are a long way from fulfilling the promise that Dihexa makes, because of non-existing funding and a pure lack of interest from scientists in the pharmacological fields. This suggests that quite some time will pass before we see Dihexa go on human trials, and even more until it is approved by the government's institutions. For now, it is reserved for the extreme cases in the health industry.

Despite logistical difficulties in the process of acquiring Dihexa, it promises not to disappear in thin air, providing a new research field for scientists in the future. Those determined to experience Dihexa, can eventually manage to get their hands on it, as it slowly becomes more accessible to the nootropic community.

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