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Dihydromyricetin for alcohol withdrawal: review, dosage, side effects

Treating Anxiety and Alcohol Withdrawal with Dihydromyricetin

What is dihydromyricetin (Dihydromyricetin)? It’s a form metabolite derived from plants known as a flavonol. Its chemical structure is as follows:

(2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Alcohol Withdrawal with DihydromyricetinAlso called Ampelopsin, this particular compound is found in nature in cedar trees as well as Japanese raisin trees. It is one of the oldest substances found in Chinese herbal medicine. Dihydromyricetin is associated with liver protection and aiding liver functions. As it can aid in resisting liver damage, it is considered hepatoprotective.

Dihydromyricetin has recently become a matter of intense interest due to its potential application as a natural hangover cure. It affects the brain’s response to alcohol. Similar flavonoids with healthy properties are found in grape seed extract and green tea. These substances also demonstrate neuro-protective qualities.

 

Effects of Dihydromyricetin

The major and most interesting effect of Dihydromyricetin is how it reacts with the brain’s response to alcohol. Dihydromyricetin has interactions with the brain’s receptor sites for GABA(A). To be more precise, Dihydromyricetin prevents alcohol molecules from binding with these receptors. Dihydromyricetin’s antagonistic action changes the mental experience of inebriation. It’s key to observe however that its effect does not extend to altering the alcohol concentration in the blood.

Medical trials with rodents have shown a complimentary effect, namely that Dihydromyricetin protects the liver against damage from alcohol. It is currently unknown how Dihydromyricetin does this but it may be related to the neural activity of the substance.

GABA is a neurotransmitter which is important for regulating the central nervous system’s neuronal activity, particularly in response to stress. As it binds to GABA receptor sites, Dihydromyricetin might mimic GABA’s ability to calm the neurological stress-response in relation to alcohol.

Some producers also make the claim that Dihydromyricetin has neuroprotective anti-oxidant abilities, pointing to its inhibitory effect on heme oxygenase-1 up-regulation. Heme oxygenase-1 is produced in the body to combat oxidative stress.

 

Benefits of Dihydromyricetin

Although Dihydromyricetin will in no way cure excess levels of blood alcohol, it may diminish some of the common side effects of intoxication, such as slurred speech, dulled cognition and motor function impairment, eg. poor balance. A single dose of Dihydromyricetin can noticeably reduce such side effects. It’s even possible for Dihydromyricetin to ameliorate or even eliminate the hangover experienced on the next day. If combined with Milk Thistle and L-Cysteine, it is even more effective as a hangover cure.

Users of Dihydromyricetin may find that after a night of hard drinking they have keen mental alertness and sharp focus, as opposed to the standard hangover symptoms of reduced drive and concentration, not to mention the dreaded headache. These neuro-protective abilities are typical of dopaminergic supplements although no direct evidence has established a link between dopamine and this promising new Dihydromyricetin supplement. Dihydromyricetin’s neuro-protective effects have yet to be studied over the longer term.
Benefits of Dihydromyricetin
 

Dihydromyricetin Dosage

The usually recommended dose of Dihydromyricetin consists of one or two 300 mg. capsules after consuming as many as six units of spirits. Increased sobriety should start to manifest almost immediately after administration. Many users take such a dosage after drinking to avoid a hangover the next day.

It remains unsafe to operate machinery, drive or partake in any other potentially risky activities after using Dihydromyricetin. You will also not pass any kind of medically-based sobriety test performed by a police officer no matter how much Dihydromyricetin you take. Do not use Dihydromyricetin in order to avoid the laws which regulate driving under the influence, it will not work.

 

Adverse Effects of Dihydromyricetin

Effects of DihydromyricetinTaking this plant-derived substance as a means to protect your liver, reduce intoxication and avoid hangovers is mostly without side effects, at least as reported during the long history of Chinese herbal medicine. Dihydromyricetin is regarded as an organic and non-toxic substance.

One reported, if indirect, “side effect” is that it may encourage users to drink to excess and to drive drunk. It causes people to exceed their regular limits in terms of alcohol consumption. While not a side effect of Dihydromyricetin itself, this tendency is nonetheless extremely dangerous. Always use a taxi, public transport or a designated driver if you intend to drink alcohol and travel.

 

Alternatives to Dihydromyricetin

Besides Dihydromyricetin, other interesting, organic smart drugs exist which can improve your brain function, even when you are suffering from a hangover. A derivative of Vitamin B6 known as Pyritinol is effective in working against the depletion of dopamine caused by alcohol consumption. Those particular supplements called cognitive metabolic enhancers also have the ability to boost a slow or tired brain without any real risk of side effects when used properly.

 

Review of Dihydromyricetin

Dihydromyricetin is a herbal medicine which has a millennia-long history of use by the Chinese. Throughout this period, it was regarded as a safe means to treat hangovers as well as conditions of the liver.

Modern science has revealed Dihydromyricetin’s interaction with the brain’s receptor sites for GABA, which goes partway towards explaining how it can reduce the experience of inebriation as well as suggesting possible mechanisms by which the drug remedies hangovers. Similar effects can be produced by metabolic cognitive enhancers, for example Pyridine. Dihydromyricetin is always a good topic for investigation due to its liver-protecting abilities. Nevertheless, Dihydromyricetin should not be considered a license to drink to excess!

 

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