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Fladrafinil vs flmodafinil vs adrafinil vs modafinil: review and comparison

Fladrafinil review

Another name for Fladrafinil is fluorafinil and its chemical designation is CRL - 40 941. It is classified as an eugeroic and its action promotes wakefulness. It is very similar in its composition and effects to modafinil and adrafinil. However, it also induces an anti-aggressive response whereas these two similar drugs do not.

On a chemical level, Fladrafinil is an adrafinil derivative, specifically a bis(p-fluro) ring-substitute. Effects additional to enhanced wakefulness include quickened cogitation. Fladrafinil also boosts neural functioning, increases recollection, and heightens ambition. It achieves these effects by activity related to histamine and dopamine neurotransmitters.

Fladrafinil is known to have minor to zero side effects, provided the recommended dosage and frequency are adhered to over a limited span of time. This drug should is NOT intended for extended usage. Using it over a lengthy period, or overdose, can harm the brain. As the drug instantly acts within the pre-synaptic cleft as a reuptake inhibitor, of both norepinephrine and dopamine, it can create related problems. For example, prolonged usage may impair the function of these neurotransmitters and give rise to cerebral blood-pathway lesions.

Fladrafinil is three to four times more effective than adrafinil. It is recommended that when beginning treatment with Fladrafinil, an introductory dose between thirty to eighty mgs be consumed over fourteen to sixteen hours. By comparison, such a dosage is considered moderate in the case of adrafinil. The introductory dose of Fladrafinil should be gradually scaled up as the system demonstrates acceptance of the drugs. However, the maximum dose should never be greater than two hundred mgs daily.

Warning: the above information has not been approved by the FDA. The drug is not provided for purposes of diagnosis, treatment, prevention or curing of any symptoms or disease. If you suffer from any ailment, always consult a medical professional before using Fladrafinil or any other medication. Do not continue the use of Fladrafinil without a further medical consultation if you experience any side effects.

Comparison to Adrafinil and Modafinil.

Fladrafinil or fluorafinil, less commonly known as fluoromodafinil or CRL - 40 941, is classed as a synthetic eugeroic or smart drug. It is very similar in its chemistry and effects to modafinil and adrafinil. In fact, it’s essentially the same substance but for the addition of a single molecule of fluoride. This addition greatly enhances its effects by making it easier for the body to absorb. The fluoride molecule explains the names fluorafinil and fluoromodafinil.

The drugs function is that of an eugeroic; that is, a drug which boosts wakefulness. The effects should be very familiar to any user of adrafinil or modafinil. Its action excites various neurotransmitters, such as histamine and dopamine. This is considered a safer pathway than alternative stimulants, such as amphetamines, which also have the potential for addiction.

Positive Effects of Fladrafinil, also known as Fluorafinil, Fluoromodafinil or CRL - 40 941.

Notable positive effects of Fladrafinil include enhanced recollection, greater mental clarity, increased ambition and an all-round higher level of mental performance. As it improves focus, it may be of use in treating conditions such as ADHD, Alzheimer’s and depression. It also has great application in the treatment of sleeping disorders, such as insomnia or narcolepsy.

Fladrafinil is generally prescribed at a potency of between thirty to one hundred mgs daily. The upper limit dose is two hundred mgs in a day and this must never be exceeded. Side effects are rare when the drug is taken according to these instructions and over the short-term only. The most commonly reported symptoms are headaches, hyperactivity, irritability, disorientation, stomach complaints and vasoconstriction.

Fladrafinil is stocked by various online suppliers. It is sold as an experimental substance for research purposes.

As with many such experimental chemicals, Fladrafinil’s cost varies extensively between the different suppliers and based on the volume purchased. Bulk purchases are always cheaper but it is recommended to test with smaller purchases; these will cost between fifteen to thirty US Dollars for a gram of crystalline powder. Bulk purchases above five hundred grams should bring the cost down to between three to ten Dollars a gram.

Simple Description of Fladrafinil

The basics of fladrafinil

Fladrafinil, otherwise known as CRL - 40 941 or fluorafinil, is a eugorics drug, which means one that increases wakefulness. It is highly similar, in both its chemistry and effects, to the drugs modafinil and adrafinil, both of which were first formulated in the ‘70s.

Fladrafinil is classed as a nootropic, a type of drug known colloquially as a “smart drug,” and used to enhance brain function. Fladrafinil not only boosts wakefulness but also memory function, focus and motivation. It is also several times more potent than either modafinil or adrafinil.


Fladrafinil was initially formulated in the 70’s as part of a range of related substances. Its calmative properties were noted and it was soon being tested in rats and humans. Such tests confirmed it to have roughly double the potency of adrafinil. The drug has since accrued a positive reputation, however it’s still not available for general purchase over the counter. Instead, it is usually purchased online as a research chemical rather than a pharmaceutical.

Positive effects

Fladrafinil serves the same intended function as adrafinil; to keep people alert and awake. This nootropic is also known to boost focus and lower tiredness, affording its users greater productivity.

The major benefit of Fladrafinil over similar drugs is its greater potency. It has been demonstrated to be at least twice as potent as adrafinil. It’s an excellent choice therefore is your system develops tolerance to adrafinil or other, similar drugs. During its development, it was noted that Fladrafinil may serve to reduce aggression. For the treatment of hyperactivity disorders, such calmative properties may well have a synergistic effect with the greater focus the drug promotes.


Adverse effects

There are no documented cases of major side effects occurring as a result of using Fladrafinil according to prescription. One of the oft-reported minor side effects is that the drug imparts a particular fragrance to one’s urine. It has also been established that the drug may cause narrowing in the blood vessels, a condition known as vasoconstriction. Some reports to be found online state these side effects outweigh the drug’s usefulness. There is as yet no clinical evidence that such effects arise from use of Fladrafinil.

Clinical investigation

Flmodafinilt’s well-known that the chemical composition of adrafinil and Fladrafinil are nearly identical. The distinguishing factor is that Fladrafinil has one of its molecular rings altered. This minor change is enough to greatly increase the drug’s bio-availability, or the rate at which the body can absorb the substance. This change is enough to greatly enhance its potency.

Like adrafinil, it’s also classed as a eugoric, in other words a drug which boosts alertness and combats the urge to sleep. Animal trials have shown the drug to lower aggression but this must still be borne out with human trials.


Use Cases

The most common uses of Fladrafinil mimic those of Adrafinil, Modafinil and related drugs. It is often take by users of those substances who have developed tolerance to them over time, although it should be noted that Fladrafinil is not considered safe for long term usage.

The prescribed use of the those drugs is in the treatment of sleeping disorders such as insomnia or narcolepsy. Fladrafinil is also highly effective for these purposes. It may also be taken off-label by those wishing to improve their work or study performance, due to its ability to increase focus, memory and general mental performance.

The drug may also be helpful for sufferers of ADHD, as it increases focus and has a calmative effect.


User reports on Fladrafinil are fairly varied, with some reporting major benefits and others remaining unconvinced of its usefulness. Many people have stated that this nootropic increases their work or academic performance due to its effects on concentration, memory and mental alertness. It’s also been reported that the drug’s effects are only mild, comparable to a regular cup of coffee. There is apparently uncertainty in certain quarters as to the drug’s ability to stave off the need for sleep. However, in all cases, there is agreement that effects vary based on dosage. Some small proportion of users also reported that the drug exacerbated their anxiety or disordered their sleep cycle. It is also fairly common to see Fladrafinil associated with reports of elevated blood pressure.

Limited Use

Using Fladrafinil for a short period should produce several noticeable effects. Such effects include enhanced focus, mental clarity and alertness. The user experience is often compared to caffeine, although without the accompanying “jitters.” On the negative side, short-term usage may lead to increased blood pressure and this should be monitored in those with already high blood pressure.

Prolonged usage
Using Fladrafinil continuously for more than a couple of weeks is not recommended. However, the longer term effects are said to include a calming effects, in addition to the expected benefits reported by short-term users. One notable side effect of long-term usage is constriction of the blood vessels. It seems from user reports that tolerance either does not develop or takes a very long time to do so.

In Summary
Fladrafinil has yet to be conclusively proven as a safe and effective nootropic. Certain users claim to have received very strong benefits from the drug, whereas the greater proportion report a milder effect, sometimes accompanied by adverse effects, notably vasoconstriction. Therefore, barring some compelling problem such as the development of tolerance, we would recommend sticking with less potent alternatives, such as adrafinil or modafinil. These smart drugs are perhaps only twice as concentrated but they are better documented, more easily-available and cheaper. Until Fladrafinil is as much of a known quantity as its “brother” drugs, it is probably best avoided by the average smart drug enthusiast.

Comparing Flmodafinil and Fladrafinil: Which is Better?

The Big Picture

Fladrafinil and Flmodafinil are not identical, as some people assume. There are minor discrepancies which can nonetheless lead to considerable differences in their comparative efficacy.

For example, Fladrafinil is generally thought to be less efficacious than Flmodafinil. This supposition is based on the observance of the mechanism of adrafinil. This closely-related substance is metabolized in the liver, becoming Flmodafinil. It is therefore assumed, by the French drug regulatory agency and others, that Fladrafinil places greater strain on the liver for no real benefit.

Applicable Research on flmodafinil vs. fladrafinil
The bulk of current clinical investigation is focused on Flmodafinil. This is not to imply that fladrafinil is ineffective. The fact is that adrafinil is fairly well-understood by comparison. Its method of action is to be metabolized by the liver into modafinil, which then crosses the blood-brain barrier to boost neural function.

Although this mechanism is well-known, the differences between Fladrafinil and Flmodafinil are far less clearly-defined. It is necessary to rely on the word of members of online sites and forums dedicated to the discussion of nootropics. Longecity and certain sub-reddits are the most likely sources. Enthusiasts on such sites will discuss these drugs with varying degrees of knowledge and objectivity, and one must learn to separate the wheat from the chaff.

Nevertheless, the scientific evidence thus far discovered does tend to support the view that both Flmodafinil and Fladrafinil are very effective agents. Flmodafinil studies have reported its effects to be comparable to those of far more dangerous amphetamine stimulants for the treatment of sleep deprivation and its associated symptoms, such as low mood and impaired mental function.

Adverse Effects of Flmodafinil and Fladrafinil
As both drugs are strong, it follows that they will have noticeable adverse effects. It is not uncommon for modafinil or adrafinil uses to report a sense of agitation, anxiousness and, occasionally, queasiness and stomach upset. Online reports either damn or praise the ability of both drugs to suppress appetite.

There is some concern over Fladrafinil’s long-term effects upon the liver. Certain users worry that consuming a drug which is converted by the liver may cause harm to that organ. It should be pointed out that this is a theoretical concern, and no such harmful effect has been reliably documented. A certain Reddit user conducted a trial on himself and found no evidence of liver impairment from using the drug. Of course, the trial was not conducted under ideal conditions and may have been too short to produce a reliable result.

Legal Advantage of Fladrafinil
The Legal Advantage of Fladrafinil

One area in which Fladrafinil has a clear and undeniable advantage is in its regulatory classification; it is unregulated and therefore entirely legal. This is distinct from modafinil, flmodafinil and similar substances, which are considered scheduled drugs and therefore available only subject to a prescription. Notwithstanding, it is a simple matter to purchase modafinil online but those who do so should be aware that they are skirting the law.

No such strictures apply to (Fl)adrafinil however, so it may be purchased and consumed without any legal concerns.

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