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Methylone vs MDMA

Methylone vs MDMA
 
First synthesized through a cooperation of Peyton Jacob III and Alexander Shulgin in 1996, this stimulant was initially created to potentially be used as an antidepressant. Currently used as an MDMA substitute, due to the fact that both of these substances provoke similar responses in the human organism. Beyond all similarities, a lot of differences also exist, unique features that only Methylone can provide for users. 
 
One of the creators of this substance has written that while Methylone has the same potency and potential to act as an antidepressant, just like MDMA, it lacks the "magic" that MDMA brings to the table. Regardless of this, Methylone is still able to provide a very pleasant and positive experience for users, which provides a lot of leverage against a condition like depression.

Methylone vs MDMA
Chemistry

The chemical markup of this substance places it in the cathinone family. As a synthetic substance Methylone (3,4-methylenedioxy-N-methylcathinone) it is very similar to the various amphetamines, like MDMA, because they host similar features in their chemical structure. A phenetylamine core connected to a phenyl ring onto which an amino group is binded through an ethyl chain, on which an additional methyl substitution exists. Because of this Methylone is considered to be an alpha-methylated phenethylamine. While chemically similar to amphetamines, cathinones like Methylone are differentiated from them by the addition of a ketone functional and carbonyl groups.

 
Pharmacology

PharmacologyThe effects of this drug over the body are comparable to other antidepressants available on the market. Let's explore the possibilities of this substance to provide a benefit in your life. It directly affects the serotonin, dopamine and norepinephrine receptors in the brain by inhibiting the reuptake of these neurotransmitters. This allows the chemicals to accumulate in the brain and be reused. These neurotransmitters are utilized in the feelings of pleasure, concentration and motivation, so users can expect a beneficial effect over these cognitive faculties when using Methylone, together with positive and pleasurable feelings. 
 
When compared to MDMA, Methylone exhibits about three times as less, when considering the effects over serotonin receptors, but when talking about norepinephrine and dopamine, the effects are similar. This causes Methylone to be less potent per dosage strength, but when looking deeper at Methylone's action mechanism you can see a two way action, that it also increases the release of these neurotransmitter, while at the same time inhibiting the reuptake, which results in an abundance of these chemicals in the brain.

 
Subjective effects

We're going to take a look at the various effects that have been recorded through personal experiences through reports and reviews on this drug. Keep in mind that these explanations and hence the following information may be biased and is certainly subjective. While this doesn't mean that its incorrect, we ask you to practice rational thought and not take anything for granted, but rather explore and research many different sources for information.

 
Physical effects

ChemistryLet's start with the effects over the body. Methylone influences the entirety of the body, providing a pleasant high, that "waves" through the body. At higher doses, it has been described as almost a overwhelming pleasantness. Following the previously mentioned effects, it makes a lot of sense, since the combined stimulation of release and inhibition of reuptake can lead to this extremely pleasurable state. 
 
As a stimulant, Methylone is increasingly similar to amphetamines like MDMA, provoking the user and motivating them to participate in physical activities. This is due to the fact that users typically feel very hyped and alive, as if they have an infinite store of energy, so they feel the need to expend and utilize it. An extremely popular choice for dancing and musical events, even raves as well. This stimulation can feel forced, especially at higher doses, where jaw tension and teeth grinding can commonly occur, just like with amphetamines where the body makes uncontrollable movements and keeping your hands calm is a faraway dream.
 
This bodily stimulation can extend to the eye muscles, where the user experiences a condition called nystagmus. What happens is that the eyes are spontaneously moved rapidly, similar to what happens during REM sleep cycles. This may cause a potentially unfocused and blurry vision.
 
Similar to other stimulants that increase the body temperature, Methylone is also increasing the activity of sweat glands, quite indirectly, by affecting and increasing the heart rate of users, while at the same time motivating them to move and engage in physical activity. It's especially important to drink water consistently under the effects of this drug, so as to not dehydrate. At the same time though, try not to over-drink water as well, as too much of a good thing is not really a good thing. At higher dosages, users may have a difficulty urinating, which is temporary and harmless, as long as you don't hydrate too much. The reason for this is that Methylone inhibits the hormones which regulate the need for urination, so one could potentially be stuck for a while in the bathroom. Urinating isn't impossible, but keep this in mind and regulate your water consumption. 
 
Safe to say that this chemical is quite interesting to utilize at music events, since similarly to MDMA it changes the appreciation that one has for music, boosting it to a new level, providing the user with a new perspective through which they listen to the sounds, seemingly for the first time.

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