Tianeptine – A Mood Brightening Drug for Depression and Anxiety
Tianeptine is a drug used for treating depression, sold under the brand names Stablon, Coaxil and Tatinol. It is viewed as one of the most effective treatments for major depressive episodes that range from mild to severe.
Tianeptine has also been used as an off-label nootropic agent and is reported to produce sensations of wellbeing, optimizing and mental clarity. The drug is marketed as having mood brightening effects as well as being neuroprotective and anxiolytic (reducing anxiety).
It is currently approved for this use in France and a number of other countries, especially throughout the European Union. It was developed at the French Society of Medical Research in the 1960’s. Because the early research was all in French, this seems to have delayed Tianeptine’s acceptance in a number of English-speaking countries.
Tianeptine is a selective Serotonin re-uptake enhancer (SSRE). This is basically a tricyclic type of anti-depressant which contains three rings of atoms in its chemical structure.
What this drug does is to enhance the re-uptake or re-absorption of Serotonin once it has been released by your neurons. This takes the Serotonin out of circulation, removing it from contact with synaptic receptors.
What is interesting is that its mechanism of action is directly opposite to how most currently prescribed anti-depressant medications work.
There are several generally accepted mechanisms of activity used to describe how Tianeptine influences the mind.
This drug is thought to somehow enhance the extracellular concentrations of Dopamine in selected brain and nerve/neuron pathways. Since Dopamine is a powerful mood boosting neurotransmitter, this can lead to some profound effects.
It has also been speculated that Tianeptine works by modulating several types of Dopamine receptors within the brain. There even appears to be some effect on Glutamate receptors, which has an important part to play in reversing impaired neuroplasticity which is often associated with stress.
Because it modulates AMPA receptors for Glutamate, this technically qualifies Tianeptine as an Ampakine.
Tianeptine is also an SSRE, causing Serotonin that is released from your neurons to be re-absorbed. Neurotransmitters are stored in tiny vesicles within the synapses of your neurons until they are released.
Once a neuron fires and release is triggered, the neurotransmitter departs the vesicle and enters the synaptic cleft where it binds to the receptors of other neurons. After this activity has ceased, the neurotransmitters are then destroyed by an enzyme or taken up again by the releasing neuron. Tianeptine increases Serotonin re-uptake so that it is removed quickly from the synaptic cleft and stored again in its neuronal vesicles.
It has also been noted that this drug seems to have a fairly short duration and does not affect the cardiovascular system in any way. This is one of the main reasons why the drug is considered safe enough to use for treating elderly patients.
what is tianeptineThe effects of Tianeptine work in a method which is counter to most of the other anti-depressant medications currently on the market.
You may have heard the term SSRI or selective Serotonin re-uptake inhibitor.
These pharmaceuticals prevent Serotonin from being taken up again by the releasing neuron, resulting in greater levels of serotonin neurotransmission. While causing reduction of anxiety and depression symptoms, these drugs are described as resulting in a mood-blunting effect due to the heightened Serotonin activity.
In contrast, SSRE’s like Tianeptine decrease Serotonin activity in the pre-frontal cortex which results in a mood enhancement effect. This is the primary reason for the drug being able to improve mood and help treat a number of the other symptoms of depression.
Tianeptine is currently being used to treat depression, especially major depressive episodes, in France and other countries throughout Europe. It is able to improve mood and relieve feelings of stress, sadness, and anxiety. It is also noteworthy that it does not appear to cause any type of tolerance, addiction, or act as a sedative substance.
Furthermore, additional evidence shows that this drug may be helpful in treating issues like obsessive compulsive disorders, social anxiety, and even some eating disorders. The possibility even exists that it could lead to medications and treatments for neuro-degenerative disorders like Alzheimer’s disease, cerebral aging, and multiple sclerosis.
Pills for this drug most often come in a 12.5 mg formulation. The generally recommended dose would be to take a single pill or tablet two or three times per day. You do want to split the dose up to ensure the body has a consistent supply of the drug.
It is suggested that new users begin with a smaller dose, perhaps cutting a tablet in half and taking this in the morning and then again at night. Only increase the dosage level once you have become familiar with its effects.
Tianeptine is a pharmaceutical drug and requires a prescription in most countries. Do not self-medicate: only use this drug under the consultation and guidance of a qualified physician who knows your medical history.
Tianeptine Side Effects
This drug is considered to be very safe and generally well-tolerated, especially by otherwise healthy adults. If you are suffering from issues like depression, it is strongly recommended that you first consult with your doctor or medical professional.
There are some side effects associated with Tianeptine. These are generally mild and include: dry mouth, constipation, dizziness, drowsiness, low blood pressure, insomnia, and possibly even some vivid dreams.
Although using Tianeptine as a Nootropic drug would certainly be considered off-label, there are people who have done so. Many of these users do indeed report seeing a variety of benefits that have been normally associated with taking Nootropics.
However, there is great variance in the available reports and many reviewers mention the occurrence of side effects. As more research is conducted into Tianeptine, it seems that the cognitive enhancement effects of this drug are likely to be attributes to its modulation of Glutamate receptors in the brain.
If you are interested in the nootropic benefits of Tianeptine, it may therefore be a better option to use a supplement like Aniracetam which also modulates Glutamate transmission. Aniracetam is known to have a mood-brightening effect as well as lessening sensations of depression and anxiety.
Tianeptine has proven to be one of the most powerful anti-depressants out there, but it should only be taken with a prescription due to the possibility of side effects.
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